'Typhoid cytokine' threatens many patients in Da Nang Covid-19

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According to Associate Professor Son, during this Covid-19 period, the Sub-Committee for Treatment did not clearly record the number of patients experiencing "cytokine storm". However, some patients have developed signs, though not causing organ failure as well as life-threatening. Currently, patients with nCoV on chronic disease must use respiratory support measures such as ECMO, mechanical ventilation, or oxygen ...

"Doctors are very aware of this syndrome, especially the high-risk group when nCoV infection will decrease resistance, making the virus grow in the body faster, damage organs faster than patients. ", Deputy Minister Son said.

In Vietnam, a 43-year-old British pilot, suffering from "cytokine storm" syndrome, had to undergo two stages of Covid-19 treatment at the Hospital for Tropical Diseases in Ho Chi Minh City and was actively resuscitated at Cho Ray Hospital.. Throughout the process, the Subcommittee of Treatment and leading experts in hospitals have formed many groups to consult to develop their own treatment regimens. Patients with cytokine storm syndrome - an overactive immune system against the body itself, 90% solidified lungs, an ECMO dependent system - extra-body oxygen circulation (artificial heart) ...

"Bão cytokine" là hiện tượng hệ miễn dịch cơ thể phản ứng quá mức, giải phóng ồ ạt cytokine gây viêm, khiến các cơ quan nội tạng suy kiệt.

"Cytokine storm" is also known as systemic inflammatory response syndrome (SIRS), cytokine release syndrome, phagocytosis syndrome, lymphohistiocytosis. The syndrome is characterized by uncontrolled proliferation of immune molecules, which can lead to organ failure, causing death. Patients with cytokine release syndrome have abnormally fast heartbeat, fever and hypotension.

The term "cytokine storm" was first mentioned in a medical paper in 1993, when researchers described the phenomenon of "grafted cell against master" appearing in transplanted people. By 2005, when the H5N1 avian influenza outbreak broke out, it began to become popular.

Cytokine release syndrome has become quite common during a pandemic. When the body is first exposed to the pathogen, the immune system is activated, beginning to fight off invading factors. At this point, cytokine molecules play a very important role, creating a series of signals for the cell to arrange a response.

Usually, the stronger the immune response, the more favorable it is to repel the virus. When the pathogen is killed or inactive, the immune system returns to its normal state. But in some cases, the immune system still works even when the virus is no longer active. It continues to release cytokines, which makes the body tired.

These molecules attack many organs, including the liver and lungs, which can eventually lead to death. At this point, the immune system, not the virus, is the body's damaging agent. Cytokine storm has many different versions and names such as systemic inflammatory response syndrome (SIRS), cytokine release syndrome, phagocytosis syndrome, lymphohistiocytosis

In addition, obesity can contribute to intense cytokine release, causing "cytokine storm" syndrome.

The mechanism of attack on the body of "cytokine storm".

Since May, New York doctors have reported a series of New York patients suffering from this condition. Cytokine storms are also a typical response for patients who die from H1N1, Sars, Mers and influenza 1918.

Researchers around the world are seeking and preparing antiviral drugs to treat Covid-19, some of which are aimed at addressing cytokine storms.

Recently, in June, the Russian Ministry of Health licensed Levilimab to treat critically ill patients. Regeneron and Sanofi are also testing an anti-inflammatory drug called Kevzara, which can inhibit the amount of cytokine produced in the body. Medication to treat arthritis. Swiss drug company Roche is studying the active ingredient Actemra, approved in 2017, specifically for this syndrome.

Thuy An - Thuc Linh

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